Monday, May 27, 2013

Economic reality finally cracks market fervor

By Andy Bruce

LONDON (Reuters) - As evidence mounts that a mid-year slowdown is taking place in the world economy, the next few days will offer a clearer glimpse of how that will impinge on policymaking and buoyant financial markets.

Global stocks stumbled last Thursday in one of the few times the grey economic reality cut through this year's reverie in financial markets.

And that could mark the start of a trend, after Federal Reserve Chairman Ben Bernanke last week hinted the U.S. central bank could soon scale back its monthly bond purchases that have flooded stock markets with new cash.

Some poor business surveys from China have also had an impact, suggesting the world's No.2 economy is struggling for momentum.

While there is little in the way of major economic data this week that will send chills through stock markets as happened on Thursday, there is a renewed sense of caution in the market.

"The underlying momentum in the global economy is weaker than it should be at this point of the economic cycle, five years after the global crisis," said Lena Komileva, director of G+ Economics consultancy in London.

"We have yet to see evidence of a convincing, self-sustained positive feedback loop between real growth and market value inflation."

Hope that market confidence would filter through to the real economy was memorably described as "positive contagion" by European Central Bank President Mario Draghi in January - in hindsight perhaps more in hope than expectation.

Growth is still proving to be elusive for the euro zone economy, largely thanks to the extent of the budget austerity taking place across the continent.

On Wednesday, the European Commission will release its review of its countries' debt-cutting policies, which will confirm that the likes of France, Spain and Slovenia are to be given more time to trim their budget deficits to target.

The Organisation for Economic Co-operation and Development's semi-annual review of the world's major economies will come out on the same day, having identified global economic activity "picking up" in its interim assessment in March.

Now, the world economic growth seems to be moving into a soft patch, although there is no sign of anything that will curb it significantly.

Last week's purchasing managers indexes showed factory activity in China declined slightly for the first time in seven months, while in the United States manufacturing grew at its slowest pace since October.

"These surveys suggest that the Chinese economy is doing a bit worse than expected and the euro zone marginally better, but they do not alter our view that global growth will remain weak, and imbalanced, for the rest of this year," said Andrew Kenningham, senior global economist at Capital Economics.

He noted, however, that economies like the UK and Japan that weren't covered in last week's PMIs have performed better than expected in recent months, so the global economy could be slightly stronger than the surveys implied.

TAKING STOCK

Since last Thursday's stock markets wobble, analysts are largely agreed that period of moderation, rather than a big correction, lies ahead for risk assets.

European markets have been particularly sensitive to shifts in sentiment over the last few years, and three Italian government bond auctions next week will provide more clues on investor intentions.

Spanish yields rose at auction for the first time in three months in the past week, and the Italian auctions will provide further interest because they will be the first since Fed Chairman Bernanke hinted that waves of new cash from central banks will not go on forever.

Governments in the euro zone's most vulnerable economies, like Spain and Italy, have benefitted hugely from reduced borrowing costs resulting from easy cash flowing out from the Fed and Bank of Japan, and into their bonds.

That of course applies to stock markets too, and Bernanke's intervention will set a new tone on global bourses in the coming weeks, marked by increased uncertainty.

The Euro STOXX 50 Volatility Index, Europe's widely used measure of investor risk aversion, surged 13 percent to a three-week high last Thursday alone.

"We remain positive on equities in general ... (but) more broadly, equity markets may lose some momentum now that they must worry about stimulus withdrawal," said Guy Foster, head of portfolio strategy at Brewin Dolphin.

(Additional reporting by David Brett; editing by Ron Askew)

Source: http://news.yahoo.com/economic-reality-finally-cracks-market-fervor-021502544.html

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Tuesday, May 21, 2013

AT&T Is Finally Going to Let Everyone Video Chat Over Data

AT&T has caught a lot of flak for being excruciatingly picky about what apps can do video chat over data on what kind of plans. It's been equal parts annoying and confusing for everyone involved. But now, the carrier is about to simplify it by letting everyone do everything by the end of this year. Finally.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/NKFLoqsCSso/at-t-is-finally-going-to-let-everyone-video-chat-over-d-508914849

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Kepler epitaph? Eight most intriguing finds of troubled telescope.

Kepler, the space telescope designed to help us find other Earth-like planets, is on the fritz. Scientists hope they will be able to fix it remotely, but if they can't, its brief, brilliant career could be over. Since it began operations in 2009, peering continuously at the same field of 145,000 stars in the constellations Cygnus and Lyra, it has found more than 2,700 planet-candidates. Here are eight of its most remarkable discoveries.?

- Mark Sappenfield,?Staff writer

This artist's conception illustrates Kepler-22b, a planet known to comfortably circle in the habitable zone of a sun-like star. (JPL-Caltech/Ames/NASA/File)

1. Kepler-22b: Goldilocks planet

Kepler has made an array of stunning discoveries ? from oddball solar systems to sun-scorched planets that orbit their stars in less than an Earth day. But Kepler-22b was the first discovery that truly validated the mission.

The goal for Kepler has always been to find Earth-mass planets orbiting sun-like stars at Earth-like distances. In other words, to find Earth's cosmic twins. Kepler-22b was perhaps a bit more like a big brother ? it's larger than Earth ? but its discovery was proof that Kepler was on the right track.

Scientists announced the discovery of Kepler-22b in December 2011. It was smack dab in the middle of its star's so-called habitable zone ? the "Goldilocks zone" close enough to allow water to be liquid but far enough to ensure that it didn't burn off. Kepler-22b orbits its sun once every 290 days. Moreover, its sun is the same G-type star as our sun, though slightly smaller and cooler.

The planet itself has a radius 2.4 times larger than Earth. Scientists are not sure about the composition of the planet, but some have suggested it could be a mini-Neptune with a global ocean and a rocky core. If it has an atmosphere, the temperature could be 72 degrees F.

"It's so exciting to imagine the possibilities," Natalie Batalha, the Kepler deputy science chief, told the Associated Press in 2011. Floating on that "world completely covered in water" could be like being on an Earth ocean, and "it's not beyond the realm of possibility that life could exist in such an ocean."

Sign up to receive a selection of Editors Picks of the best stories of the week every Saturday.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/zC4V-ON0r-k/Kepler-epitaph-Eight-most-intriguing-finds-of-troubled-telescope

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Reference and Education: Elsevier and the Russian Education and ...

Elsevier, the world-leading publisher of scientific, technical and medical information products and services provider, and the Russian Ministry of Education and Science the Russian Award winners announced Scopus 2013.

The Scopus Award Scheme, held in Russia in 2005, aimed at supporting Russia to honor its outstanding scientists and research. This year's event is co-sponsored by Elsevier and the Russian Education and Science and the Russian Foundation for Basic Research Foundation (RFBR) and the Russian Academy of Sciences support.

This year, the selection criteria is based on the data in the world's largest peer-reviewed abstracts and citation database Scopus. The selection criteria included the h-index score, the number of publications and references, as well as at the national level academic recognition. The award consists of Russia, Youngsuk "YS" Chi, Elsevier and Dr. Elsevier President of Russia and Belarus Regional Director Igor Osipov Mr. Andrei Polyakov, Ministry of Science and Education.

The six award winners are:

Outstanding contribution to the field of computer science:

Sergei Obiedkov - Associate Professor, Department of Applied Mathematics and Information Science, National Research University Higher School of Economics, Moscow, Russian Federation.

Outstanding contributions to the field of physics:

The Dr. Ruslan Metsaev, - researchers PN column Lebedev Physics Institute, Moscow, Russian Federation.

Outstanding contribution to the field of chemistry:

Andre Cheprakov - Moscow, Russian Federation, Moscow State University, Department of Chemistry, associate professor.

For outstanding contributions to the field of biology:

Dr. Konstantin Lukyanov - Biophotonics Laboratory, Institute of Bioorganic Chemistry, Moscow, Head of the Russian Federation.

For outstanding contribution to the field of social sciences:

Professor Helena Slobodskaya (MD, Sc.D.) - Principal Research Scientist, Institute of Physiology, basic medicine, Novosibirsk, Russian Federation Novosibirsk State University.

Early career researchers:

Alexander Chernov (PhD) - Research Fellow, Institute of General Physics, Moscow, Russian Federation.

Scopus awards ceremony to commemorate the Russian Academy of Sciences brightest individuals is an important event, we share with the celebration of the Russian Science and Elsevier glad, and hope that these awards inspire our researchers to continue their findings and to change the world become a better , Andrei Polyakov, deputy director of the Department of the development of science and technology, Education and Science Mr. said.

The "YS" Youngsuk Chi, Chairman of Elsevier, which means that Elsevier is honored to participate in this celebration in the Russian research proved the bright prospects of the Russian scientific research achievements of six very talented. Working with Russia Over the years, Elsevier goal is to continue to support Russian researchers with the highest quality content and state-of-the-art solutions and we are pleased today to see the results of our lasting cooperation. "

Scopus Award Presentation Ceremony, held at the Grand Hotel Europe, May 14, 2013, before the International Congress. Congress multidisciplinary discussion further scientific point of view and technologies, and the development of higher education in Russia meeting point. Congress participants and speakers, research, education and business areas, including the RFBR Deputy Chairman Vladimir Kvardakov (), a member of the Richard Berg (research and innovation, the EU delegation to Russia), Andrea Poli Yaakov (deputy director of the Russian Ministry of Education and version) Youngsuk "YS" Chi (Chairman, Elsevier), as well as many other experts in science, education and business.

With regard to the Russian Education and Science Ministry,

Ministry of Education and Science is a federal agency of executive power, the development of national policies and norms of legitimate regulatory activities in education, science, science and technology and innovation, nanotechnology, the field of intellectual property, and in the field of upbringing, social support and protection of students in educational institutions.

About Scopus

SCOPUS global coverage of the research literature, is the world's largest peer-reviewed abstracts and citation database. Have smart tools to track, analyze and visualize research, The Scopus design and development input from more than 500 users and international librarians. Its unique database contains nearly 20,500 peer-reviewed journals more than 5,000 publishers around the world to ensure that cover a wide range of interdisciplinary abstracts and references. Direct link to the subscription full text of the articles, library resources and other applications like reference management software, make Scopus quicker, easier and more comprehensive to use than any other literature research tool.

About Elsevier

Elsevier is a world-leading publisher of scientific, technical and medical information products and service providers. Company with the global science and health communities to publish more than 2,000 journals, including the Lancet and cell, and close to 20,000 book title, major reference works from Moss and Sanders. Elsevier's online solutions, including SCIENCEDIRECT, SCOPUS, Reaxys ClinicalKey and Moss suites, which enhance the productivity of science and health professionals, and the SciVal suite and MEDai accurate evaluation, which help research and health care institutions to provide better the result is more cost-effective.

A global business headquartered in Amsterdam, Elsevier employs more than 7,000 people in the world. The company is part of Reed Elsevier Group, the world's leading provider of professional information technology solutions. The Group employs more than 30,000 people, including more than 15,000 in North America. Reed Elsevier Group also has two parent companies, Reed Elsevier PLC and Reed Elsevier NV. Their shares listed for trading on the London, Amsterdam and New York Stock Exchange, stock code: London: REL Amsterdam,: any New York: RUK and ENL.

Source: http://referenceeducationc.blogspot.com/2013/05/elsevier-and-russian-education-and.html

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Monday, May 20, 2013

Small Fla. city wonders who won $590.5 million Powerball jackpot

ZEPHYRHILLS, Fla. (AP) ? Some lucky person walked into a Publix supermarket in suburban Florida over the past few days and bought a ticket now worth an estimated $590.5 million ? the highest Powerball jackpot in history.

But it wasn't Matthew Bogel. On Sunday, he loaded groceries into his car after shopping at the Publix. He shook his head when asked about the jackpot.

"It's crazy, isn't it?" he said. "That's so much money."

It's an amount too high for many to imagine. Compare it to the budget for the city of Zephyrhills: This year's figure is just more than $49 million. The winning Powerball jackpot is 12 times that.

Whoever has the ticket hadn't come forward as of Sunday morning.

"This would be the sixth Florida Powerball winner and right now, it's the sole winner of the largest ever Powerball jackpot," Florida Lottery executive Cindy O'Connell told The Associated Press. "We're delighted right now that we have the sole winner."

Publix spokeswoman Maria Brous said that there are a lot of rumors about who won, but the store doesn't know. "We're excited for the winner or winners," she said.

O'Connell said Florida has had more Powerball winners than any other state but did not give any indication whether anyone had stepped forward with the winning ticket in Saturday's drawing.

But plenty of people in Zephyrhills ? population 13,337 ? are wondering whether it's someone they know.

Joan Albertson drove to the Publix early Sunday morning with her camera in hand, in case the winner emerged. She said she had bought a ticket at a store across the street, and the idea of winning that much money was still something of a shock.

"Oh, there's so much good that you could do with that amount of money." Albertson said. "I don't even know where to begin."

Zephyrhills is a small city in Pasco County, about 30 miles northeast of downtown Tampa. Once a rural farming town, it's now known as a hotbed for skydiving activity, and the home to large retiree mobile home parks and Zephyrhills bottled water.

And now, one lucky lottery ticket.

"I'm getting text messages and messages from Facebook going, 'uh, did you win the lottery?'" Sandra Lewis said. "No, I didn't win, guys. Sorry."

Sara Jeltis said her parents in Michigan texted her with the news Sunday morning.

"Well, it didn't click till I came here," she said, gesturing to the half-dozen TV live trucks humming in the Publix parking lot. "And I'm like, wow I can't believe it, it's shocking! Out of the whole country, this Publix, in little Zephyrhills would be the winner."

With four out of every five possible combinations of Powerball numbers in play, lottery executives said Saturday that someone was almost certain to win the game's highest jackpot, a windfall of hundreds of millions of dollars ? and that's after taxes.

The winning numbers were 10, 13, 14, 22 and 52, with a Powerball of 11.

Estimates had earlier put the jackpot at around $600 million. But Powerball's online site said Sunday that the jackpot had reached an estimated $590.5 million.

The world's largest jackpot was a $656 million Mega Millions jackpot in March 2012.

Terry Rich, CEO of the Iowa Lottery, initially confirmed that one Florida winning ticket had been sold. He told AP that following the Florida winner, the Powerball grand prize was being reset at an estimated jackpot of $40 million, or about $25.1 million cash value.

The chances of winning the prize were astronomically low: 1 in 175.2 million. That's how many different ways you can combine the numbers when you play. But lottery officials estimated that about 80 percent of those possible combinations had been purchased recently.

While the odds are low for any one individual or individuals, O'Connell said, the chance that one hits paydirt is what makes Powerball exciting.

"There is just the chance that you will have the opportunity, and Florida is a huge Powerball state," O'Connell said. "We have had more winners than any other state that participates in Powerball."

The longshot odds didn't deter people across Powerball-playing states ? 43 plus Washington, D.C., and the U.S. Virgin Islands ? from lining up at gas stations and convenience stores Saturday.

Clyde Barrow, a public policy professor at the University of Massachusetts-Dartmouth, specializes in the gaming industry. He said one of the key factors behind the ticket-buying frenzy is the size of the jackpot ? people are interested in the easy investment.

"Even though the odds are very low, the investment is very small," he said. "Two dollars gets you a chance."

Lewis, who went to the Publix on Sunday to buy water, said she didn't play ? and she isn't upset about it.

"Life goes on," she said, shrugging. "I'm good."

___

Rodriguez reported from Des Moines, Iowa.

___

Follow Tamara Lush at http://twitter.com/tamaralush.

Follow Barbara Rodriguez at http://twitter.com/bcrodriguez.

Source: http://news.yahoo.com/small-fla-city-wonders-won-powerball-jackpot-163342761.html

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Sports insurance and Sports National Governing Bodies.


I encountered a paper from BMJ recently on the topic.
http://bjsm.bmj.com/content/25/1/21.full.pdf

It's full of interesting factoids:

"Information on 36 of the 39 sports surveyed (92%) was sufficient for analysis. Twenty-two of these 36 sports
(61%) organized insurance at a national level, one at club level (3%) and 13 (36%) provided no insurance advice. Only 12 sports (33%) insisted on mandatory insurance cover. Many sportsmen and women are left to search for an appropriate insurance cover themselves or remain uninsured. Owing to the lack of advice in 36% of cases it was decided to survey ... insurance brokers to establish what type of policy they would recommend. Only 41% of the brokers were able to offer a suitable policy. Club policies recommended by the Central Council for Physical Recreation provide individuals with the same sports cover (but at a lower premium) as is available from a personal accident policy. However, cover is somewhat inadequate and may provide a false sense of security."

They give lots of info about which sports end up in which hospital department amking up what share of the workload, and then finish, saying:

"We feel it would be a responsible action of the national governing bodies of sports to make insurance mandatory at club level. This would provide support in the event of sports-related disablement for
members who would not otherwise be insured. We believe that all governing bodies of sports for Wales
should organize a suitable and adequate insurance policy to be taken out at club level on behalf of
members and that the premium be included in the dub membership fee. At present only a handful of
sports, seven of 36 (19%), have such a policy"

Source: http://www.fencingforum.com/forum/showthread.php?18022-Sports-insurance-and-Sports-National-Governing-Bodies.

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Sunday, May 19, 2013

University of Glasgow makes 3D models with single-pixel sensors, skips the cameras (video)

University of Glasgow creates 3D with singlepixel sensors, skips the cameras video

Most approaches to capturing 3D models of real-world objects involve multiple cameras that are rarely cheap, and are sometimes tricky to calibrate. The University of Glasgow has developed a method that ditches those cameras altogether. Its system has four single-pixel sensors stitching together a 3D image based on the reflected intensity of light patterns cast by a projector. Reducing the pixel count lowers the cost per sensor to just a few dollars, and extends the sensitivity as far as terahertz wavelengths. Real-world products are still a long way off, but the university sees its invention as useful for cancer detection and other noble pursuits. Us? We'd probably just waste it on creating uncanny facsimiles of ourselves.

Filed under: ,

Comments

Via: New Scientist

Source: University of Glasgow

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/56GltFVQtCI/

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Monday, May 13, 2013

How does Benghazi affect Clinton? (CNN)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/305402306?client_source=feed&format=rss

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Climate change will cause widespread global-scale loss of common plants and animals, researchers predict

May 12, 2013 ? More than half of common plants and one third of the animals could see a dramatic decline this century due to climate change, according to research from the University of East Anglia.

Research published today in the journal Nature Climate Change looked at 50,000 globally widespread and common species and found that more than one half of the plants and one third of the animals will lose more than half of their climatic range by 2080 if nothing is done to reduce the amount of global warming and slow it down.

This means that geographic ranges of common plants and animals will shrink globally and biodiversity will decline almost everywhere.

Plants, reptiles and particularly amphibians are expected to be at highest risk. Sub-Saharan Africa, Central America, Amazonia and Australia would lose the most species of plants and animals. And a major loss of plant species is projected for North Africa, Central Asia and South-eastern Europe.

But acting quickly to mitigate climate change could reduce losses by 60 per cent and buy an additional 40 years for species to adapt. This is because this mitigation would slow and then stop global temperatures from rising by more than two degrees Celsius relative to pre-industrial times (1765). Without this mitigation, global temperatures could rise by 4 degrees Celsius by 2100.

The study was led by Dr Rachel Warren from UEA's school of Environmental Sciences and the Tyndall Centre for Climate Change Research. Collaborators include Dr.Jeremy VanDerWal at James Cook University in Australia and Dr Jeff Price, also at UEA's school of Environmental Sciences and the Tyndall Centre. The research was funded by the Natural Environment Research Council (NERC).

Dr Warren said: "While there has been much research on the effect of climate change on rare and endangered species, little has been known about how an increase in global temperature will affect more common species.

"This broader issue of potential range loss in widespread species is a serious concern as even small declines in these species can significantly disrupt ecosystems.

"Our research predicts that climate change will greatly reduce the diversity of even very common species found in most parts of the world. This loss of global-scale biodiversity would significantly impoverish the biosphere and the ecosystem services it provides.

"We looked at the effect of rising global temperatures, but other symptoms of climate change such as extreme weather events, pests, and diseases mean that our estimates are probably conservative. Animals in particular may decline more as our predictions will be compounded by a loss of food from plants.

"There will also be a knock-on effect for humans because these species are important for things like water and air purification, flood control, nutrient cycling, and eco-tourism.

"The good news is that our research provides crucial new evidence of how swift action to reduce CO2 and other greenhouse gases can prevent the biodiversity loss by reducing the amount of global warming to 2 degrees Celsius rather than 4 degrees. This would also buy time -- up to four decades -- for plants and animals to adapt to the remaining 2 degrees of climate change."

The research team quantified the benefits of acting now to mitigate climate change and found that up to 60 per cent of the projected climatic range loss for biodiversity can be avoided.

Dr Warren said: "Prompt and stringent action to reduce greenhouse gas emissions globally would reduce these biodiversity losses by 60 per cent if global emissions peak in 2016, or by 40 per cent if emissions peak in 2030, showing that early action is very beneficial. This will both reduce the amount of climate change and also slow climate change down, making it easier for species and humans to adapt."

Information on the current distributions of the species used in this research came from the datasets shared online by hundreds of volunteers, scientists and natural history collections through the Global Biodiversity Information Facility (GBIF).

Co-author Dr Jeff Price, also from UEA's school of Environmental Studies, said: "Without free and open access to massive amounts of data such as those made available online through GBIF, no individual researcher is able to contact every country, every museum, every scientist holding the data and pull it all together. So this research would not be possible without GBIF and its global community of researchers and volunteers who make their data freely available."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/XAcUhs4tZmA/130512140946.htm

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IRS official knew in 2011 of 'Tea Party' targeting: watchdog report

By Kim Dixon and Patrick Temple-West

WASHINGTON (Reuters) - A senior U.S. Internal Revenue Service official knew in 2011 that IRS agents were giving extra scrutiny to conservative Tea Party groups, according to documents from a watchdog office obtained by Reuters on Saturday.

In a scandal that has already embarrassed the IRS and become a distraction for the Obama administration, a report from the Treasury Department's Inspector General For Tax Administration (TIGTA) was expected to be issued publicly next week on the IRS practice, who knew about it and when.

As more information emerged over the weekend, the White House said President Barack Obama was concerned about the conduct of a few IRS employees.

White House spokesman Jay Carney said: "If the inspector general finds that there were any rules broken or that conduct of government officials did not meet the standards required of them, the president expects that swift and appropriate steps will be taken to address any misconduct."

The TIGTA report finds that Lois Lerner, who heads the IRS's tax-exempt groups unit, knew of the extra scrutiny as early as June 2011.

On Friday, in remarks that triggered a storm of controversy, Lerner publicly apologized at a legal conference in Washington for what she termed "inappropriate" targeting by the IRS of conservative groups applying for tax-exempt status.

She said the practice was confined to an IRS office in Cincinnati and that it was "absolutely not" influenced by the Obama administration. She said none of the targeted groups was denied tax-free status.

The TIGTA report was requested last year by Republican Representative Darrell Issa, chairman of a congressional investigative panel, after he accused the IRS of targeting conservative groups.

TIGTA has found that the IRS singled out groups with the words "Tea Party" or "patriot" in their names for closer scrutiny, according to a TIGTA document.

IRS CHIEF DENIED KNOWLEDGE

In March 2012 in congressional testimony, then-IRS Commissioner Doug Shulman said the IRS was not making it harder for conservative groups to become tax-exempt.

Shulman stepped down at the end of 2012 when his term ended. Steven Miller was named acting head of the agency.

The IRS said in a statement on Saturday that the TIGTA report was correct. The statement said officials in the IRS exempt organizations division knew of the screening and that "IRS senior leadership did not have this level of detail."

The statement said that while "mistakes were made," there "were not partisan reasons behind this."

Although part of the executive branch, the IRS is considered an independent agency and officials try to stay out of politics.

According to the TIGTA document, the IRS was singling out the conservative groups as early as March 2010.

The document says managers in the "determinations unit" told specialists to be on the lookout for applications from organizations linked to the Tea Party, a political movement that favors smaller government and fewer and lower taxes.

CHANGING CRITERIA

The IRS screening criteria were broadened in July 2011 to cover "organizations involved with political, lobbying or advocacy" seeking tax exemption, according to a TIGTA timeline of events.

Further broadening of the criteria occurred in January 2012 and again in May 2012, the document said.

Issa has vowed to investigate the matter and the House committee he chairs has the power to issue subpoenas. At least one other congressional panel intends to hold hearings, giving Republicans multiple opportunities to hammer the agency and the White House over the affair that had been brewing for months.

Lerner said IRS agents in Cincinnati targeted conservative groups "without talking to managers." The staffers were trying to deal with a crush of applications for tax-exempt status by using key words to get through the paperwork faster, she said.

About 300 applications were initially flagged for closer scrutiny. Of those, 75 were chosen for that treatment based on the presence of the key words in their names.

THOUSANDS OF APPLICATIONS

Each year the IRS reviews as many as 60,000 tax-exempt applications from groups ranging from charities to labor unions. Some are classified as 501(c)(4) groups after the section of the tax code that makes them tax-exempt. Such organizations can collect money from anonymous donors and spend it on advertising.

To get and keep their tax-exempt status, 501(c)(4) groups cannot endorse a political candidate or a political party.

The number of groups seeking 501(c)(4) status more than doubled from 2010 to 2012, coinciding in part with the surge of Tea Party enthusiasm. In 2010 the U.S. Supreme Court issued its "Citizens United" decision lifting government limits on corporate spending in federal elections.

Consumer groups have been pushing the IRS to clarify the standards for "social welfare organizations," as they are known in Section 501(c)(4) of the tax code, to ensure that they are not abusing their tax-exempt status.

(Additional reporting by Mark Felsenthal; Writing by Kevin Drawbaugh; Editing by Kevin Drawbaugh, Xavier Briand and Bill Trott)

Source: http://news.yahoo.com/senator-blasts-irs-over-tea-party-apology-hearings-011345359.html

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Sunday, May 12, 2013

National Observers Note Irregularities in Pakistan Elections (Voice Of America)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/305251011?client_source=feed&format=rss

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N.M. woman arrested after faking cancer - KRQE-TV.com

ALBUQUERQUE (KRQE) - A New Mexico woman is accused of faking cancer and setting up a fake charity to raise money for others with the disease but then pocketing that money.

Elizabeth Bateman, a Los Alamos native, turned herself into the Steamboat Springs Police Department in Colorado Friday morning.

According to police documents Bateman told everyone she had terminal cancer.

"She said that she wanted to start an organization that helped young adults with terminal illnesses something similar to the Make-A-Wish Foundation," said Nicole Kofoed.

With the help of friends Bateman created the Friends Through the Fight Foundation.? A single fundraiser held in Colorado where Bateman was living last year raised $7,000.

It is money everyone thought was going to help others, but according to police Bateman was helping herself with the cash, going on cruises, skydiving and taking helicopter and hot air balloon rides.

"It was heartbreaking, ? I didn't know what to think at first," Kofoed said.

Kofoed grew up with Bateman in Los Alamos.

In an interview with KRQE News 13 she said she reached out to Bateman on Facebook when she learned of the cancer.? At the time, Kofoed's mother had recently died from the disease.

"Elizabeth seemed to ask me a lot of questions about what I had been through with my mom, and I was very open and honest with her because I thought I was helping," she said.

But now, Kofoed thinks Bateman was using those details to further her own story because the 34-year-old never had cancer.

According to court documents, Bateman made the story up going as far as shaving her head and pretending to have morphine injections.? The morphine turned out to be saline solution.

Another friend said she even took Bateman from Colorado to Chimay?.

"She wanted to go to get this sacred dirt so she could be healed," Michelle Beck said.

Bateman's con unraveled in March.? She was sick, and a friend took her to the hospital where Bateman claimed she had received treatment for her cancer.

However, the doctors said there was no record of her ever undergoing cancer treatment there.

At that point, Bateman bolted and according to her brother moved to Albuquerque.

"She's already in New Mexico like making new friends and talking to them and telling them God knows what," said Beck.

Police said Bateman also pulled the fake cancer scam in Texas.

According to friends there have been fundraisers for Bateman in New Mexico.

Source: http://www.krqe.com/dpp/news/crime/nm-woman-arrested-after-faking-cancer

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The Cleveland Abductions, School Cheating Scandals, and Dogs, Dogs, Dogs

168283480 The house of Amanda Berry's sister, one of the three women held captive for a decade, stands decorated by well wishers May 7, 2013 in Cleveland.

Photo by Emmanuel Dunand/AFP/Getty Images

?Being Amanda Berry: Our morbid fascination with the real-life tales of abducted girls,? by Emily Bazelon. Ordeals like Amanda Berry?s ?are our gothic horror stories, our Bluebeards come to life,? and we often treat such events like sensational nightmares. Bazelon reminds us of the long journey Gina DeJesus, Michelle Knight, Berry and her daughter all have ahead in recovering from such an experience.

??No, I Do Not Want to Pet Your Dog: They?re lounging in our offices and licking us at our caf?s. It?s time to take America back,? by Farhad Manjoo. After encountering a loud Doberman at his gym of all places, Manjoo questions the ubiquity of dogs in our society. Not everyone likes dogs, after all. He compares dog lovers with parents of toddlers, like himself, and finds that parents are a little more considerate. ?Whenever I go into public spaces with my toddler, I treat him as if I were handling nuclear waste or a dangerous animal.?

?Failing the Test: Why cheating scandals and parent rebellions are erupting in schools in New York, Washington, D.C., and Atlanta,? by David L. Kirp. Education reform based primarily on test scores alienates teachers and doesn?t help students, Kirp claims. He cautions that there are no quick fixes for our current problems and makes the case for trusting teachers and encouraging them to collaborate.

??The Problem With Handsome, Enigmatic Men: They?re boring,? by Simon Doonan. Characters like Jay Gatsby and Don Draper may be attractive, but they?re not very interesting. Doonan breaks down the characteristics you need to be popular despite lacking a personality but warns that such ?attractive grumpsters? usually don?t get happy endings. Speaking of Gatsby, check out Dana Stevens? review of the movie, out this weekend, and play Slate?s Gatsby video game.

?The Weight of the Presidency: The fact that New Jersey Gov. Chris Christie?s weight-loss surgery is both personal and political is the true sign that he is a contender,? by John Dickerson. Gov.? Christie recently underwent lap-band surgery, supposedly for personal health reasons. Dickerson lays out how losing weight could help him if he runs for president in 2016.

?Elmo Fever: Why are kids so obsessed with that short red Sesame Street muppet?? by Melinda Wenner Moyer. The short answer: He?s just like them. Moyer explains that toddlers love Elmo because he interacts with the world in the same curious way they do. His eye-catching red fur doesn?t hurt either.

???Violence Against Women Can Be Funny: In defense of the Onion?s story about Chris Brown?s desire to beat Rihanna to death,? by Hanna Rosin. Should some topics be off limits for satire? Rosin doesn?t think so?what?s important is how well you do it. The Onion?s story may be horrifying, but it?s also hilarious and ?brings more attention to domestic violence than 100 earnest blog posts on the same subject ever could.?

?Don?t Fear the 3-D Gun: Yes, it will be possible to make weapons with 3-D printers. No, that doesn?t make gun control futile,? by Farhad Manjoo. Law student and activist Cody Wilson uploaded plans for a homemade gun to the Internet, but don?t panic?gun control is still important and helpful. Manjoo crunches the numbers on why 3-D printed guns won?t overtake the mass-produced kind anytime soon.

?Are We Good? Comedian Marc Maron?s unlikely career is at a crossroads,? by David Haglund. With a new TV show, memoir, and stand-up special coming out, Marc Maron is more visible than ever before. Long-time fan Haglund looks back at Maron?s rise to prominence and explores how narcissism defines his work (to everyone?s benefit).

?Dodgeball Should Not Be Part of Any Curriculum, Ever: Making kids play team sports in PE is neither healthy nor educational,? by Jessica Olien. Physical education is meant to improve kids? health and teach them to work together. But Olien argues that team sports do neither, but they do destroy the confidence of those who are less athletically inclined.

Source: http://feeds.slate.com/click.phdo?i=271cb4c6493dcc250360438d776e32b1

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Norway's Crown Prince And Princess Talk Startups And Try Out The Oculus Rift

royal couple norwayNorway's Crown Prince Haakon and his wife Princess Mette-Marit were in Silicon Valley this week, and I asked them about their hopes to bring more startups and innovation to their home country. I interviewed Haakon and Mette-Marit at Norway's Innovation House Silicon Valley, a co-working space in Palo Alto for Norwegian startups looking to enter the US market. The couple saw demos from several startups ? the prince even tried on some Oculus Rift virtual reality goggles ? it was part of Making View's demo of its technology for capturing and exploring 360-degree video footage. (He said it was "pretty awesome.")

Source: http://feedproxy.google.com/~r/Techcrunch/~3/jCGwior9iP8/

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Why Prince Harry meets US vets in Colorado (+video)

Britain's Prince Harry, a veteran combat helicopter pilot, met Saturday with military vets competing in the Paralympic-style Warrior Games in Colorado.

By Dan Elliott,?Associated Press / May 11, 2013

Britain's Prince Harry, right, listens to Colorado Gov. John Hickenlooper, center, at a reception at the Sanctuary Golf Course in Sedalia, Colo., on Friday, May 10, 2013.

(AP Photo/Ed Andrieski, Pool)

Enlarge

Britain's Prince Harry chatted and joked with wounded service members from the United Kingdom on Saturday at the Warrior Games, the U.S. military's Paralympic-style competition in Colorado.

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The prince, a veteran combat helicopter pilot, mingled with the 35-member British team and then sat on a gymnasium floor in a circle of 12 sitting volleyball team members, batting the ball around amid whoops and laughter.

The veterans said Harry's combat experience made him easy to talk to.

"He knows what it's like out there," said British Army Capt. Dave Henson, a member of the volleyball team. "He's been on the ground and in the air."

Henson, 28, lost both legs when an improvised bomb exploded in Afghanistan two years ago. He said Harry took a personal interest in the athletes' recovery and the quality of their health care.

Royal Marine Matthew Hancox, 25, said the prince recognized some wounded veterans he had met before and asked them how they were recovering.

"He's very down-to-earth," said Hancox, who was shot in the chest in Afghanistan in 2011.

The prince also planned to attend a volleyball match and the opening ceremonies at the Olympic training center in Colorado Springs later Saturday.

The visit to Colorado got underway Friday night when Harry charmed dozens of dignitaries, British expatriates, students and military officers at a cocktail party welcoming him to Colorado. He also joined the crowd in singing "Happy Birthday" to U.S. Olympic swimmer Missy Franklin, who was celebrating turning 18 at a golf club south of Denver.

A captain in Britain's Army Air Corps, Harry has deployed to Afghanistan twice, and he wore a brown camouflage uniform and tan combat boots when he met with the British team.

His first deployment, as a forward air controller in 2007-2008, was cut short after 10 weeks when details of his whereabouts were disclosed in the media.

On his second deployment, he was a co-pilot and gunner on an Apache helicopter.

He acknowledged to reporters he had targeted Taliban fighters, and when asked if he had killed anyone, said, "Yeah, so, lots of people have."

He's attending the Colorado games because he believes the wounded deserve recognition, according to a statement from St. James' Palace in London, the official residence of the royal family.

"He seemed very interested in what stage we are all in in terms of our rehabilitation," said Erica Vey, a veteran of the British Air Force.

Vey, who competes in track and field and shooting, had a leg amputated after an injury she suffered when a cargo plane had to take sudden evasive action.

"He was quite easy to talk to," she said of the prince.

Harry caused a scandal on his last trip to the U.S. when he was photographed frolicking nude with an unidentified woman in a Las Vegas hotel suite in August.

"It was probably a classic example of me probably being too much army, and not enough prince," he said afterward.

The Warrior Games run through Thursday. They also include basketball, shooting, archery, swimming and track and field. About 260 athletes are expected.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/rnXoxKKP_Io/Why-Prince-Harry-meets-US-vets-in-Colorado-video

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Saturday, May 11, 2013

Regular Exercise Slashes Breast Cancer Risk

Women who take the time to exercise on a regular basis are less likely to develop breast cancer at some point in their lives, a study published in the journal Cancer Epidemiology says.

For the time being, breast cancer is considered by specialists to be the most common type of invasive cancer to affect women in all parts of the world.

Because of this, the news that a woman's risks of being affected by this condition can be reduced with the help of regular physical activity alone proved to be a head-turner.

The researchers now claiming that exercise slashes cancer risk base their affirmations on their having discovered that physical activity (aerobics in particular) changes the way in which estrogen is broken down and metabolized in the body.

More precisely, they say that, as far as they can tell, physical activity ups the so-called good to bad ratio of estrogen metabolites inside the body.

This in turn reduces a woman's risk of developing breast cancer.

Data suggesting that regular aerobic exercise ups said ratio were collected while conducting a clinical trial involving a total of 391 women volunteers.

The women were all young, healthy and premenopausal.

Medical News Today quotes Mindy S. Kurzer, Ph.D., currently working as a professor in the Department of Food Science and Nutrition at the University of Minnesota in Saint Paul, who commented on the findings of this study as follows:

?Observational studies suggest physical activity lowers breast cancer risk, but there are no clinical studies that explain the mechanism behind this.?

?Ours is the first study to show that aerobic exercise influences the way our bodies break down estrogens to produce more of the 'good' metabolites that lower breast cancer risk.?

Presently, the researchers are unable to explain why it is that aerobic exercise affects the way a woman's body deals with estrogen.

It is to be expected that further investigations will shed more light on the underlying mechanisms of this phenomenon.

Source: http://news.softpedia.com/news/Regular-Exercise-Slashes-Breast-Cancer-Risk-351847.shtml

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Friday, May 10, 2013

The IRS and Obama?s Enemies List (Powerlineblog)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/304935583?client_source=feed&format=rss

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Cleveland man charged with 3 women's kidnap, rape

This undated photo released by the Cleveland Police Department shows Ariel Castro. Three women who disappeared in Cleveland a decade ago were found safe Monday, May 8, 2013 and police arrested three brothers, including Castro, accused of holding the victims against their will. (AP Photo/Cleveland Police Department)

This undated photo released by the Cleveland Police Department shows Ariel Castro. Three women who disappeared in Cleveland a decade ago were found safe Monday, May 8, 2013 and police arrested three brothers, including Castro, accused of holding the victims against their will. (AP Photo/Cleveland Police Department)

This undated photo released by the Cleveland Police Department shows Ariel Castro. Three women who disappeared in Cleveland a decade ago were found safe Monday, and police arrested three brothers, including Castro, accused of holding the victims against their will. (AP Photo/Cleveland Police Department)

Gina DeJesus gives a thumbs-up as she is escorted toward her home Wednesday, May 8, 2013, in Cleveland. The three women held captive for about a decade at a run-down Cleveland house were apparently bound with ropes and chains, police said Wednesday, while charges were expected by the end of the day against the three brothers under arrest. (AP Photo/Tony Dejak)

Felix DeJesus pumps his fist after bringing home his daughter, Gina, Wednesday, May 8, 2013, in Cleveland. The three women held captive for about a decade at a run-down Cleveland house were apparently bound with ropes and chains, police said Wednesday, while charges were expected by the end of the day against the three brothers under arrest. (AP Photo/Tony Dejak)

Felix DeJesus pumps his fist after bringing his daughter, Gina, home Wednesday, May 8, 2013, in Cleveland. The three women held captive for about a decade at a run-down Cleveland house were apparently bound with ropes and chains, police said Wednesday, while charges were expected by the end of the day against the three brothers under arrest. (AP Photo/Tony Dejak)

(AP) ? A man suspected of keeping three women captive inside his decrepit house for a decade was charged Wednesday with kidnapping and rape, accused of holding them under conditions so oppressive they were allowed outside for only a few moments in disguise and never saw a chance to escape until this week.

Investigators said the women apparently were bound with ropes and chains, and a city councilman briefed on the case said they were subjected to prolonged sexual and psychological abuse and suffered miscarriages.

Ariel Castro, a 52-year-old former school bus driver, was charged with four counts of kidnapping ? covering the captives and the daughter born to one of them ? and three counts of rape, against all three women.

The women, now in their 20s and 30s, vanished separately between 2002 and 2004. At the time, they were 14, 16 and 20 years old.

Prosecutors brought no charges against Castro's two brothers, who were arrested along with him on Monday, saying there was no evidence they had any part in the crime.

Castro owns the run-down home where the women were rescued on Monday after one of them, Amanda Berry, broke through a screen door to freedom while he was away. The discovery electrified Cleveland, where many people had come to believe the missing young women were dead.

Police Deputy Chief Ed Tomba said it was the only opportunity they ever had to escape.

"Something must have clicked, and she saw an opportunity and she took that opportunity," he said.

Tomba said the women could remember being outside only twice during their time in captivity.

"We were told they left the house and went into the garage in disguise," he said.

The women were not kept in the same room but knew about one another, he said.

He also said a paternity test on Castro was being done to establish who fathered Berry's 6-year-old daughter.

At a news conference, authorities would not discuss the circumstances of the women's kidnappings or give further details about their ordeals. But City Councilman Brian Cummins said: "We know that the victims have confirmed miscarriages, but with who, how many and what conditions we don't know."

"It sounds pretty gruesome," he added.

Castro was in custody Wednesday and couldn't be reached for comment. A brother-in-law has said the family was shocked after hearing about the women at the home.

Neighbors said that over the years, Castro took part in the search for one of the women, Gina DeJesus, helped pass out fliers, performed music at a fundraiser for her and attended a candlelight vigil, at which he comforted her mother.

None of the women said anything that indicated Castro's brothers, Pedro Castro, 54, and Onil Castro, 50, were involved, Tomba said.

"Ariel kept everyone at a distance," he said.

A court hearing for Ariel Castro was set for Thursday morning.

The deputy chief also said there was no evidence to indicate any of the women had been outside without clothes, despite claims from a neighbor who said a naked woman was seen crawling around the backyard.

Cleveland police have disputed claims by neighbors that officers had been called to the house before for suspicious circumstances. They said nothing in their records supports that.

Earlier Wednesday, Berry, 27, and DeJesus, who is in her early 20s, were welcomed home by jubilant crowds of loved ones and neighbors with balloons and banners. Family members protectively took them inside, past hundreds of reporters and onlookers.

Neither woman spoke.

"Give us time and privacy to heal," said Sandra Ruiz, DeJesus' aunt. Ruiz urged the public not to retaliate against the Castros or their families.

DeJesus' father pumped his fist after arriving home with his daughter and urged people across the country to watch over the children in their neighborhoods, including other people's kids.

"Too many kids these days come up missing, and we always ask this question: How come I didn't see what happened to that kid? Why? Because we chose not to," he said

The third captive, Michelle Knight, 32, was reported in good condition at Metro Health Medical Center, which a day earlier had reported that all three victims had been released. There was no immediate explanation from the hospital.

The Associated Press does not usually identify people who may be victims of sexual assault, but the names of the women were widely circulated by their families, friends and law enforcement authorities for years during their disappearances and after they were found.

Castro also was questioned about 14-year-old Ashley Summers, who disappeared near his house in 2007. But Tomba said there was no new information linking that case to Castro.

While prosecutors announced charges against Castro, federal agents searched a vacant house near where the women had been held. Officials would not say why they were there.

A 2005 domestic-violence filing in Cuyahoga County Domestic Relations Court accused Castro of twice breaking the nose of his children's mother, knocking out a tooth, dislocating each shoulder and threatening to kill her and her daughters three or four times in a year.

The filing for a protective order by Grimilda Figueroa also said that Castro frequently abducted her daughters and kept them from her. Figueroa died a year ago.

___

Associated Press writers Andrew Welsh-Huggins, Jesse Washington and Mike Householder and freelance reporter John Coyne in Cleveland; Mitch Stacy in Columbus; Dan Sewell in Cincinnati; John Seewer in Toledo; and news researchers Rhonda Shafner and Jennifer Farrar in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-08-Missing%20Women%20Found/id-8df31b5f82c946d0b3e4fb7a9c7f5e5e

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France confirms 1st case of new SARS-related virus

(AP) ? A 65-year-old Frenchman is hospitalized after contracting France's first case of a deadly new respiratory virus related to SARS, and French health authorities said Wednesday they are trying to find anyone who might have been in contact with him to prevent it from spreading.

It's unclear how or where the man was infected with the novel coronavirus, which has killed 18 people in four countries and raised new public health concerns since being identified last year in the Middle East. It can cause acute pneumonia and kidney failure.

The Frenchman fell ill after returning from a trip to the United Arab Emirates, the Health Ministry said. He has been under isolation and medical surveillance at a hospital in Douai in northern France since April 23, and is receiving respiratory assistance and blood transfusions, said Jean-Yves Grall, the government health director.

Paris' Pasteur Institute analyzed the man's virus and confirmed that it is a novel coronavirus, the ministry announced Wednesday.

Since September 2012, the World Health Organization has been informed of 30 confirmed cases of the virus, and 18 of the patients have died. Cases have been emerged in Saudi Arabia, Jordan, the UAE, Qatar, Britain and Germany, and health officials have said the virus has likely already spread between people in some circumstances.

France's health minister, Marisol Touraine, said "this is an isolated case" in France but said authorities are "fully mobilized" to prevent it from spreading. Authorities are trying to reach anyone who was in contact with the patient before he was hospitalized, and a national hotline was established Wednesday for the public to call about the virus.

WHO has advised countries to test any people with unexplained pneumonia.

"Any virus that has the potential to develop into something that is highly transmissible between people, including the coronavirus, is a major concern," WHO spokesman Gregory Hartl said.

"We need to follow up on all possible routes of infection, i.e. animal to human, whether it's being spread in hospitals or from human-to-human," he said.

Health authorities are trying to determine how humans are contracting and spreading the virus and how best to treat it. It does not appear to be as contagious as SARS or the flu, but it has probably spread between people who had close contact. It seems to have spread among family members in Britain and in health workers in Jordan who were caring for patients, for example.

The new coronavirus is most closely related to a bat virus and scientists are considering whether bats or other animals like goats or camels are a possible source of infection.

"We still don't know the animal reservoir of this virus or the source of exposure," Hartl said. "We need a solid epidemiological investigation to nail down a common behavior between patients...All we can tell people at the moment is they should be very vigilant about their basic hygiene practices."

He said it's unclear whether there is something specific in the environment in the Middle Eastern countries where cases have been confirmed.

Several cases have been reported in Saudi Arabia. In the most recent Saudi outbreak, the Health Ministry has said five people have died and at least five others are hospitalized with confirmed cases of the virus.

SARS, or severe acute respiratory syndrome, killed some 800 people in a 2003 epidemic.

___

Maria Cheng in London contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-05-08-EU-France-Virus/id-1349e32c7bb24938b666945cb38037cc

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Thursday, May 9, 2013

Epigenomics of stem cells that mimic early human development charted

May 9, 2013 ? Scientists have long known that control mechanisms known collectively as "epigenetics" play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development.

Now, in the first comprehensive analysis of epigenetic changes that occur during development, a multi-institutional group of scientists, including several from the Salk Institute for Biological Studies, has discovered how modifications in key epigenetic markers influence human embryonic stem cells as they differentiate into specialized cells in the body. The findings were published May 9 in Cell.

"Our findings help us to understand processes that occur during early human development and the differentiation of a stem cell into specialized cells, which ultimately form tissues in the body," says co-lead author Joseph R. Ecker, a professor and director of Salk's Plant Molecular and Cellular Biology Laboratory and holder of the Salk International Council Chair in Genetics.

Scientists have established that the gene expression program encoded in DNA is carried out by proteins that bind to regulatory genes and modulate gene expression in response to environmental cues. Growing evidence now shows that maintenance of this process depends on epigenetic marks such as DNA methylation and chromatin modifications, biochemical processes that alter gene expression as cells divide and differentiate from embryonic stem cells into specific tissues. Epigenetic modifications -- collectively known as the epigenome -- control which genes are turned on or off without changing the letters of the DNA alphabet (A-T-C-G), providing cells with an additional tool to fine-tune how genes control the cellular machinery.

In their study, the Salk researchers and their collaborators from several prominent research institutions across the United States examined the beginning state of cells, before and after they developed into specific cell types. Starting with a single cell type -- the H1 human embryonic stem cell, the most widely studied stem cell line to date -- the team followed the cells' epigenome from development to different cell states, looking at the dynamics in changes to epigenetic marks from one state to another. Were they methylated, an essential process for normal development, or unmethylated? What happened to the cells during development? What regulatory processes occurred in the cell lineage?

The scientists found sections of the DNA that activate regulatory genes, which in turn control the activity of other genes, tend to have different amounts of letters of the DNA alphabet, "C" and "G" specifically, depending on when these regulatory genes are turned on during development. Additionally, regulatory genes that control early development are often located on stretches of DNA called methylation valleys, or DMVs, that are generally CG rich and devoid of epigenetic chemical modifications known as methylation.

Consequently, these genes have to be regulated by another epigenetic mechanism, which the authors found were chemical changes called chromatin modifications. Chromatin is the mass of material -- DNA and proteins -- in a cell's nucleus that helps to control gene expression.

On the other hand, genes active in more mature cells whose tissue type is already determined tend to be CG poor and regulated by DNA methylation. The results suggest that distinct epigenetic mechanisms regulate early and late states of embryonic stem cell differentiation.

"Epigenomic studies of how stem cells differentiate into distinct cell types are a great way to understand early development of animals," says Ecker, who is also a Howard Hughes Medical Institute and Gordon and Betty Moore Foundation Investigator. "If we understand how these cells' lineages originate, we can understand if something goes right or wrong during differentiation. It's a very basic study, but there are implications for being able to produce good quality cell types for various therapies."

For example, says Matthew Schultz, a graduate student in Ecker's lab, "understanding how development plays out normally could give us clues about how to reverse the process and turn normal adult cells into stem cells to regenerate tissues."

One area where the findings may help is in the study of tumor development. In normal tissue, DMVs are unmethylated, but in cancer, especially breast, colon and lung cancer, they are hypermethylated, suggesting, says Ecker, that alterations in the DNA methylation machinery might be an important mechanism aiding tumor development. He says further investigation is required to develop a greater understanding of this process.

Other researchers on the study were Matthew D. Schultz, Ryan Lister, Joseph R. Nery, Mark A. Urich and Huaming Chen, from the Salk Institute; Wei Xie, Nisha Rajagopal, R. David Hawkins, Danny Leung, Ah Young Lee, Audrey Kim, Samantha Kuan, Chia-an Yen, Sarit Klugman, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye and Bing Ren of the Ludwig Institute for Cancer Research; Zhonggang Hou, Shulan Tian, Scott A. Swanson, Jiuchun Zhang, Pengzhi Yu, Nicholas E. Propson, Jessica E. Antosiewicz-Bourget, Ron Stewart and James A. Thomson of the Morgridge Institute for Research; Pradipta Ray Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung and Michael Q. Zhang of the University of Texas at Dallas; John W. Whitaker, Hongbo Yang, Tao Wang, Yun Zhu, Neil C. Chi, and Wei Wang of the University of California, San Diego; and Kran Suknuntha and Igor Sluvkin of the University of Wisconsin.

The study was supported by the National Institutes of Health Epigenome Roadmap Project, the National Heart, Lung and Blood Institute, and the American Heart Association.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/E86AFfaqYI0/130509133155.htm

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